Is there an option to auto mute videos by default?
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There does not seem to be such option, and neither do I see an open issue about this.
A few of them are about volume control, but I would encourage you to create a new issue asking specifically for default mute:
https://github.com/TeamNewPipe/NewPipe/issuesI use an automation app called MacroDroid, it lets you do all sorts of stuff.